The CWC27 Polyclonal Antibody (PAC020410) is a valuable tool for researchers studying the CWC27 protein, which plays a crucial role in pre-mRNA splicing. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CWC27 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in molecular biology and RNA splicing research.CWC27 is a key component of the spliceosome, a complex molecular machinery responsible for removing introns from pre-mRNA molecules.
Dysregulation of splicing processes has been linked to various human diseases, including cancer and genetic disorders. Therefore, understanding the function of CWC27 is essential for unraveling the mechanisms underlying these conditions and developing targeted therapies.By utilizing the CWC27 Polyclonal Antibody in your research, you can gain valuable insights into the role of the CWC27 protein in pre-mRNA splicing and its implications for human health. This antibody is a reliable tool for investigating RNA processing pathways and uncovering new therapeutic targets in the field of molecular biology.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Human liver cancer tissue, Human normal colon tissue, human placenta tissue, Primary antibody: PACO20410(CWC27 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20410(CWC27 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CWC27 belongs to the cyclophilin-type PPIase family and contains 1 PPIase cyclophilin-type domain. There are two isoforms. PPIases accelerate the folding of proteins.
Synonyms:
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
UniProt Protein Function:
SDCCAG10: PPIases accelerate the folding of proteins. Belongs to the cyclophilin-type PPIase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 5.2.1.8; RNA splicing; Spliceosome; IsomeraseChromosomal Location of Human Ortholog: 5q12.3Molecular Function: peptidyl-prolyl cis-trans isomerase activityBiological Process: nuclear mRNA splicing, via spliceosome
