The CUL7 Polyclonal Antibody (PAC013676) is an essential tool for researchers studying CUL7, a protein involved in cell cycle regulation and protein degradation pathways. This antibody, produced in rabbits, shows high specificity and sensitivity when used with human samples and is validated for use in Western blot applications. Its ability to specifically recognize the CUL7 protein enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and cancer research.CUL7 is a crucial component of the E3 ubiquitin ligase complex, which is responsible for tagging proteins for degradation, thereby regulating key cellular processes such as cell cycle progression and DNA repair.
Dysregulation of CUL7 has been linked to various diseases, including cancer, making it a promising therapeutic target for drug development. By studying the function of CUL7, researchers can gain insights into the molecular mechanisms underlying disease pathology and potentially identify new strategies for treatment.Overall, the CUL7 Polyclonal Antibody is a valuable tool for researchers investigating the role of CUL7 in cellular processes and disease development. Its high specificity and sensitivity, along with its versatility in different experimental settings, make it an essential resource for advancing scientific understanding in the fields of cell biology and cancer research.
CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; microtubule cytoskeleton organization and biogenesis; positive regulation of dendrite morphogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; epithelial to mesenchymal transition; regulation of mitosis; vasculogenesis; Golgi organization and biogenesis; placenta developmentDisease: Three M Syndrome 1
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
