The CTSK Polyclonal Antibody (PAC026033) is a valuable tool for researchers studying Cathepsin K, a lysosomal cysteine protease involved in bone resorption and remodeling. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to Cathepsin K, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in osteoporosis, osteoarthritis, and other bone-related diseases.
Cathepsin K is a key player in bone metabolism, as it is responsible for degrading collagen and other matrix proteins in the bone. Dysregulation of Cathepsin K activity has been linked to various bone disorders, making it a promising target for therapeutic intervention. The CTSK Polyclonal Antibody provides researchers with a powerful tool to further explore the role of Cathepsin K in bone health and disease, ultimately contributing to the development of novel treatments for bone-related conditions.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO26033 at dilution of 1:20.
Background:
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid, pH. May play an important role in extracellular matrix degradation By similarity.
Synonyms:
Cathepsin K (EC 3.4.22.38), Ctsk
UniProt Protein Function:
CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.
Biological Process: bone resorption; collagen catabolic process; intramembranous ossification; proteolysis; proteolysis involved in cellular protein catabolic process
NCBI Summary:
putative protease; human homolog displays endoprotease activity and is associated with pycnodysostosis when mutated [RGD, Feb 2006]
