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CTLA4 Monoclonal Antibody [PAT4F2AT] (CPAB0074)

SKU:
CPAB0074
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT4F2AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

CTLA4 Monoclonal Antibody [PAT4F2AT] (CPAB0074)

The CTLA4 Polyclonal Antibody (CPAB0074) is a valuable tool for researchers studying immune regulation and immune responses. Raised in rabbits, this antibody is highly reactive with human samples, specifically binding to the CTLA4 protein. Its validation for use in Western blot applications allows for the detection and analysis of CTLA4 in various cell types, making it ideal for immunology and cancer research studies.CTLA4, also known as cytotoxic T-lymphocyte-associated protein 4, is a crucial checkpoint molecule that regulates T cell activation and immune responses. By inhibiting the co-stimulatory signals necessary for T cell activation, CTLA4 plays a key role in maintaining immune tolerance and preventing autoimmune diseases.

Its involvement in immune regulation makes it a promising target for therapies aimed at modulating immune responses in conditions such as cancer and autoimmune disorders.Researchers interested in understanding the mechanisms of immune regulation and exploring new therapeutic strategies can benefit from the use of the CTLA4 Polyclonal Antibody (CPAB0074) in their studies. Its specificity and reliability in detecting CTLA4 make it a valuable tool for investigating the role of this important immune checkpoint molecule in health and disease.

Product Name:CTLA4 Antibody
Product Sku:CPAB0074
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CTLA4 mAb, clone PAT4F2AT, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CTLA4 protein 36-161 amino acids purified from Ecoli.
Clone:PAT4F2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CTLA4 antibody was purified by protein-A affinity chromatography.
Isotype:IgG1
Background:CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Synonyms:GSE, CD152, IDDM12, CELIAC3, CTLA-4.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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