The CTAGE5 Polyclonal Antibody (PACO58725) is a valuable tool for researchers studying CTAGE5, a protein involved in the regulation of immune responses and cell signaling pathways. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CTAGE5, also known as Integral membrane protein TMBIM6, is known to play a role in cellular stress response and apoptosis. By targeting CTAGE5 with this antibody, researchers can detect and study the protein in various cell types, helping to unravel its function in immune regulation and potential implications in diseases such as cancer and inflammatory conditions.
With its high reactivity and specificity for CTAGE5, this polyclonal antibody is a valuable tool for researchers investigating the molecular mechanisms underlying immune function and disease pathology. Its potential applications in immunology and cancer research make it a crucial resource for advancing our understanding of CTAGE5 and its role in human health.
Antibody Name:
CTAGE5 Antibody (PACO58725)
Antibody SKU:
PACO58725
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Endoplasmic reticulum export factor CTAGE5 protein (515-632AA)
IHC image of PACO58725 diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.
Synonyms:
Endoplasmic reticulum export factor CTAGE5 (CTAGE family member 5 ER export factor) (Protein cTAGE-5) (Meningioma-expressed antigen 6/11), CTAGE5, MEA11 MEA6 MGEA11 MGEA6
UniProt Protein Function:
CTAGE5: Tumor-associated antigen. Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Belongs to the cTAGE family. 8 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Membrane protein, integralChromosomal Location of Human Ortholog: 14q13.3Cellular Component: endoplasmic reticulum membrane; membraneMolecular Function: enzyme activator activity; protein bindingBiological Process: ER to Golgi vesicle-mediated transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
