The CSTL1 Polyclonal Antibody (PACO22294) is a vital tool for researchers studying CSTL1, a key enzyme involved in the degradation of extracellular matrix proteins. This antibody, generated in rabbit hosts, exhibits high reactivity towards human samples and is suitable for use in Western blotting and immunohistochemistry applications. By specifically targeting the CSTL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in the fields of enzymology and cancer research.CSTL1, also known as Cathepsin L1, plays a crucial role in tissue remodeling processes by breaking down collagen and other components of the extracellular matrix.
Dysregulation of CSTL1 activity has been implicated in various pathological conditions, including cancer metastasis and fibrotic disorders. Investigating the function and expression of CSTL1 can provide valuable insights into disease mechanisms and potential therapeutic targets. The CSTL1 Polyclonal Antibody is a valuable tool for researchers working towards a better understanding of these complex processes.
Antibody Name:
CSTL1 Antibody (PACO22294)
Antibody SKU:
PACO22294
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CSTL1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunofluorescence analysis of A549 cells, using CSTL1 antibody.
Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined.
Synonyms:
Cystatin-like 1; RCET11;
UniProt Protein Function:
CSTL1: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined. [provided by RefSeq, Jul 2008]Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 20p11.21Cellular Component: extracellular regionMolecular Function: cysteine protease inhibitor activity
UniProt Protein Details:
NCBI Summary:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined. [provided by RefSeq, Jul 2008]
