The CST11 Polyclonal Antibody (PACO22292) is a valuable tool for researchers studying CST11, an important protein involved in immune regulation processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CST11 protein, researchers are able to accurately detect and analyze its expression in various cell types, making it an ideal tool for studies in immunology and cancer research.CST11, also known as immune regulatory protein, plays a key role in maintaining immune balance by modulating immune responses and inhibiting inflammatory reactions.
Its role in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CST11 is crucial for the development of therapies that can modulate immune responses in these disease contexts. Overall, the CST11 Polyclonal Antibody is a valuable resource for researchers looking to delve into the complexities of immune regulation and inflammation, offering a reliable tool to study the role of CST11 in various disease settings.
Antibody Name:
CST11 Antibody (PACO22292)
Antibody SKU:
PACO22292
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CST11.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from A549 cells, using CST11 antibody.
Background:
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.
Synonyms:
Cystatin-11;
UniProt Protein Function:
CST11: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleusMolecular Function: cysteine protease inhibitor activityBiological Process: defense response to bacterium
UniProt Protein Details:
NCBI Summary:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
