The CSN3 Polyclonal Antibody (PACO58721) is a highly specific antibody designed for research involving CSN3, a key component of the COP9 signalosome complex. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.CSN3 plays a crucial role in regulating the activity of the COP9 signalosome complex, which is involved in the proteasomal degradation pathway and various cellular processes such as cell cycle control and DNA repair. Dysregulation of CSN3 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a valuable target for research in these areas.
By using the CSN3 Polyclonal Antibody, researchers can effectively detect and analyze the expression of CSN3 in different cell types and tissues, providing valuable insights into its function and role in disease pathogenesis. This antibody is a valuable tool for studies in molecular biology, cell biology, and cancer research, ultimately contributing to a better understanding of CSN3 biology and its potential therapeutic implications.
IHC image of PACO58721 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Synonyms:
Kappa-casein, CSN3, CASK CSN10 CSNK
UniProt Protein Function:
CSN3: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. Belongs to the kappa-casein family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 4q13.3Cellular Component: extracellular region; extracellular spaceMolecular Function: protein bindingBiological Process: lactation; protein stabilization; transmembrane transport
