The CSMD1 Polyclonal Antibody (PACO19521) is a valuable tool for researchers studying CSMD1, a cell surface molecule with roles in immune regulation and cancer. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CSMD1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in both immunology and oncology research.CSMD1, known for its involvement in cell adhesion and signaling pathways, is a key player in immune response modulation and cancer progression. Its functions in immune regulation and tumor suppression make it a promising target for research into cancer, autoimmune diseases, and inflammatory conditions.
Understanding the role of CSMD1 is crucial for developing targeted therapies that manipulate immune responses and inhibit cancer growth.In conclusion, the CSMD1 Polyclonal Antibody (PACO19521) is a high-quality tool for researchers investigating the functions of CSMD1 in immune regulation and cancer. Its specificity, reliability, and versatility make it a valuable asset for advancing our understanding of disease mechanisms and developing novel therapeutic strategies.
Antibody Name:
CSMD1 Antibody (PACO19521)
Antibody SKU:
PACO19521
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CSMD1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19521(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19521(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the CSMD1gene. It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas.
Synonyms:
CUB and Sushi multiple domains 1
UniProt Protein Function:
CSMD1: Potential suppressor of squamous cell carcinomas. Belongs to the CSMD family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p23.2Cellular Component: integral to membrane
