The CREB3L4 Polyclonal Antibody (PACO08593) is a valuable tool for researchers studying the CREB3L4 protein, which plays a key role in cellular processes such as transcriptional regulation and cell proliferation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.CREB3L4, also known as cAMP responsive element-binding protein 3-like 4, is involved in the unfolded protein response pathway, which is critical for maintaining cellular homeostasis under stress conditions.
Dysregulation of CREB3L4 has been linked to diseases such as cancer and neurodegenerative disorders, making it a promising target for therapeutic development.By using the CREB3L4 Polyclonal Antibody, researchers can accurately detect and analyze CREB3L4 expression in various cell types, allowing for a deeper understanding of its function in both normal and disease states. This antibody is an essential tool for studies in molecular biology, cancer research, and drug discovery related to CREB3L4 and its associated pathways.
cAMP responsive element binding protein 3-like 4;CREB3L4;AIBZIP;ATCE1;CREB3;CREB4;JAL;hJAL ;
UniProt Protein Function:
CREB3L4: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Belongs to the bZIP family. ATF subfamily.Protein type: Transcription factor; Endoplasmic reticulum; Membrane protein, integralChromosomal Location of Human Ortholog: 1q21.3Cellular Component: endoplasmic reticulum; Golgi apparatusBiological Process: positive regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
