100% Quality Guarantee
PhD-Level Technical Support
Key Features

CD35/CR1 Rabbit Monoclonal Antibody (CAB3661)

Datasheet MSDS
SKU CAB3661
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Rabbit
Synonyms KN, C3BR, C4BR, CD35, CD35/CR1
Research Use Immunology
€131 - €457

Request a formal quotation

A PDF quote with its own quote number, ready for your purchasing office to raise a PO against. Back within 4 working hours, from a PhD scientist — not an autoresponder.

  • PO-ready PDFQuote number, VAT, Incoterms
  • Volume pricing appliedDiscounts from 2 kits up
  • Valid 30 daysPrices held while you get sign-off
Anything we should know? optional

No account needed. We use your details only to prepare and send this quote. If it's urgent, say so in the box and we'll come back the same working day.
Global Shipping: 80+ Countries
White Glove Service: Available upon request
Batch Consistency: Contact Sales
Distributors: 60+ Countries
Contact Sales Quote or discount
Find Distributor 50+ countries
Technical Support PhD-level team
Live Chat Available now

Description

system_update_altDatasheetsystem_update_altMSDS

CD35/CR1 Monoclonal Antibody (CAB3661)

The CD35/CR1 Monoclonal Antibody (CAB3661) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced and validated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various research applications, including Western blotting and immunohistochemistry.CD35, also known as Complement Receptor 1 (CR1), plays a crucial role in the immune system by recognizing and clearing pathogens and immune complexes. Dysregulation of CD35/CR1 has been implicated in various autoimmune disorders, infections, and inflammatory conditions.

This antibody is validated for use in IHC-P, ELISA, IF-P, mIHC applications and has demonstrated reactivity against Human samples.

Product Name:CD35/CR1 Monoclonal Antibody
SKU:CAB3661
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC2065
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:DGYT LEGS PWSQ CQAD DRWD PPLA KCTS RTHD ALIV GTLS GTIF FILL IIFL SWII LKHR KGNN AHEN PKEV AIHL HSQG GSSV HPRT LQTN EENS RVLP
Tested Applications:IHC-P ELISA IF-P mIHC
Recommended Dilution:
IF-P1:100 - 1:500
IHC-P1:100 - 1:500
mIHC1:100 - 1:500
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:KN, C3BR, C4BR, CD35, CD35/CR1
Cellular Localization:Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:224kDa

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.

Purification MethodAffinity purification
Gene ID1378
RRIDAB_2863107
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human tonsil using CD35/CR1 Rabbit mAb (CAB3661) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageConfocal imaging of paraffin-embedded Human tonsil tissue using CD35/CR1 Rabbit mAb (CAB3661, dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform high pressure antigen retrieval with 0.01 M citrate buffer (pH 6.0) prior to IF staining.
Product ImageThe multiplex IHC analysis on paraffin-embedded Human stomach cancer tissue using the following specific primary antibodies and tyramide signal amplification (TSA) reagents (RK05903) : CD35/CR1 Rabbit mAb (CAB3661, 1:100) with TSA-TYR-520 (Green), CD3E Rabbit mAb (CAB19017, 1:2000) with TSA-TYR-570 (Red), and Ki67 Rabbit mAb (CAB20018, 1:500) with TSA-TYR-690 (cyan). DAPI (Blue) was used for nuclear staining. Prior to multiplex IHC staining, high-pressure antigen retrieval was performed using 0.01M citrate buffer at pH 6.0. The analysis was completed using a 20x objective lens.
View AllClose

0 Reviews

Write a Review
0
Based on 0 reviews

No reviews yet. Be the first to share your experience!

View AllClose

Related Products