The CR1 Polyclonal Antibody (CAB10059) is a valuable tool for research involving CR1, a cell surface molecule known for its role in immune regulation and immune response modulation. This antibody is produced in rabbits and shows high reactivity with human samples, making it a reliable option for Western blot applications. By binding to the CR1 protein, researchers can detect and analyze CR1 in various cell types, making it a versatile tool for studies in immunology and cancer research.CR1, also known as complement receptor 1, is a key player in immune homeostasis by regulating the complement system and immune responses.
Its involvement in immune function makes it a potential target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of CR1 is essential for developing new therapies that modulate immune function and potentially treat these diseases effectively. Overall, the CR1 Polyclonal Antibody (CAB10059) is a valuable resource for researchers looking to investigate the functions of CR1 in immune regulation and its implications in various diseases.
Product Name:
CD35/CR1 Rabbit Polyclonal Antibody
SKU:
CAB10059
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 420-550 of human CD35/CD35/CR1 (NP_000642.3).
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
Purification Method:
Affinity purification
Gene ID:
1378
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of U-937 cells, using CD35/CD35/CR1 antibody (CAB10059) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
