The COX7C Antibody (PACO08556) is a valuable tool for researchers studying the COX7C protein, a crucial component of the mitochondrial respiratory chain complex III. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the COX7C protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for studies in mitochondrial biology, metabolism, and related disease pathways.COX7C is essential for maintaining proper mitochondrial function and energy production, as it plays a key role in electron transport and ATP synthesis.
Dysregulation of COX7C has been implicated in various metabolic disorders, mitochondrial diseases, and neurodegenerative conditions. By studying the expression and activity of COX7C using this antibody, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially uncover new therapeutic targets for intervention.Overall, the COX7C Antibody (PACO08556) is a valuable tool for investigating the role of COX7C in mitochondrial function and metabolism, offering new opportunities for advancements in research on mitochondrial diseases and related disorders.
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]
