The COX7B2 Polyclonal Antibody (PAC013914) is a valuable tool for research involving COX7B2, a mitochondrial protein essential for cellular respiration and energy production. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for studying COX7B2 expression and localization in a variety of cell types.COX7B2 is a subunit of cytochrome c oxidase, a key enzyme in the electron transport chain that is crucial for ATP synthesis. Dysregulation of COX7B2 has been implicated in various metabolic disorders and mitochondrial dysfunction-related diseases.
Therefore, studying the expression and function of COX7B2 using this antibody is essential for gaining insights into the role of mitochondria in health and disease.Validated for use in Western blot applications, this antibody enables precise detection and analysis of COX7B2 protein levels in research related to metabolism, bioenergetics, and mitochondrial function. Its high reactivity and specificity make it a valuable asset for scientists investigating the molecular mechanisms underlying mitochondrial dysfunction and its implications in human health.
Antibody Name:
COX7B2 Antibody (PACO13914)
Antibody SKU:
PACO13914
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human COX7B2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO13914(COX7B2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX7b (cytochrome c oxidase subunit VIIb polypeptide) and COX7b2 (cytochrome c oxidase subunit VIIb polypeptide 2) are 80 and 81 amino acid, proteins, respectively, which exist as components of the COX complex, therefore playing an important role in electron transport. A rare polymorphism in the COX7b2 gene at codon 26 may be linked to nasopharyngeal carcinoma (NPC), the most common head and neck cancer in southern China.
Synonyms:
cytochrome c oxidase subunit VIIb2
UniProt Protein Function:
COX7B2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.Protein type: Membrane protein, integral; Mitochondrial; OxidoreductaseChromosomal Location of Human Ortholog: 4p12Cellular Component: integral to membrane; mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activity
