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COX7B Antibody (PACO13911)

SKU:
PACO13911
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • COX7B Antibody PACO13911
  • COX7B Antibody PACO13911
  • COX7B Antibody PACO13911
$407
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Description

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COX7B Antibody (PACO13911)

The COX7B Antibody (PAC013911) is a polyclonal antibody designed for research involving COX7B, a subunit of cytochrome c oxidase involved in electron transport and ATP production in the mitochondria. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications including Western blotting. COX7B is a critical component of the electron transport chain and plays a key role in mitochondrial function and energy production. Its significance in cellular respiration makes it a valuable target for studies in mitochondrial dysfunction, metabolic disorders, and diseases related to impaired energy production.

Understanding the function and expression of COX7B can provide insights into the mechanisms underlying these conditions and aid in the development of potential therapeutic strategies.Overall, the COX7B Antibody is a valuable tool for researchers studying mitochondrial biology, bioenergetics, and related diseases, allowing for the detection and analysis of COX7B protein expression in various cell types and tissues. Its high specificity and sensitivity make it ideal for use in immunology, cancer research, and other fields where mitochondrial function is a focus of investigation.

Antibody Name:COX7B Antibody (PACO13911)
Antibody SKU:PACO13911
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Rat
Immunogen:Fusion protein of human COX7B
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO13911(COX7B Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageGel: 10+15%SDS-PAGE, Lysate: 50 μg, Lane: 293T cells, Primary antibody: PACO13911(COX7B Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO13911(COX7B Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200).
Background:Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.
Synonyms:Cytochrome c oxidase subunit VIIb
UniProt Protein Function:COX7B: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.Protein type: Membrane protein, integral; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: Xq21.1Cellular Component: mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activityBiological Process: cellular metabolic process; central nervous system development; transmembrane transportDisease: Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism, And Other Congenital Anomalies
UniProt Protein Details:
NCBI Summary:Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
UniProt Code:P24311
NCBI GenInfo Identifier:4502991
NCBI Gene ID:1349
NCBI Accession:NP_001857.1
UniProt Secondary Accession:P24311,Q6ICR1, B2R4M3
UniProt Related Accession:P24311
Molecular Weight:9,161 Da
NCBI Full Name:cytochrome c oxidase subunit 7B, mitochondrial
NCBI Synonym Full Names:cytochrome c oxidase subunit VIIb
NCBI Official Symbol:COX7B  
NCBI Official Synonym Symbols:APLCC  
NCBI Protein Information:cytochrome c oxidase subunit 7B, mitochondrial; cytochrome-c oxidase chain VIIb; cytochrome c oxidase polypeptide VIIb
UniProt Protein Name:Cytochrome c oxidase subunit 7B, mitochondrial
UniProt Synonym Protein Names:Cytochrome c oxidase polypeptide VIIb
Protein Family:Cytochrome c oxidase
UniProt Gene Name:COX7B  
UniProt Entry Name:COX7B_HUMAN
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