COX17 Antibody (PACO35582)
- SKU:
- PACO35582
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
COX17 Antibody (PACO35582)
The Cox17 Polyclonal Antibody (PAC035582) is a research tool designed for studying Cox17, a protein involved in copper metabolism and mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By targeting the Cox17 protein, researchers can detect and analyze its expression in different cell types, making it a valuable tool for investigations in biochemistry and cellular biology.
Cox17 is a key player in the delivery of copper to cytochrome c oxidase, an essential enzyme in the electron transport chain of mitochondria. Dysregulation of copper homeostasis and impaired mitochondrial function have been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. By understanding the role of Cox17 in these processes, researchers can uncover potential therapeutic targets for treating mitochondrial dysfunction and associated conditions.
| Antibody Name: | COX17 Antibody (PACO35582) |
| Antibody SKU: | PACO35582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cytochrome c oxidase copper chaperone protein (1-63AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: COX17 antibody at 3.5µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 7 kDa. Observed band size: 7 kDa. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO35582 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO35582 at dilution of 1:100. |
| Background: | Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). |
| Synonyms: | Cytochrome c oxidase copper chaperone, COX17 |
| UniProt Protein Function: | COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylationChromosomal Location of Human Ortholog: 3q13.33Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane spaceMolecular Function: copper ion binding; copper chaperone activityBiological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14061 |
| NCBI GenInfo Identifier: | 5031645 |
| NCBI Gene ID: | 10063 |
| NCBI Accession: | NP_005685 |
| UniProt Secondary Accession: | Q14061 |
| UniProt Related Accession: | Q14061 |
| Molecular Weight: | |
| NCBI Full Name: | cytochrome c oxidase copper chaperone isoform b |
| NCBI Synonym Full Names: | cytochrome c oxidase copper chaperone COX17 |
| NCBI Official Symbol: | COX17Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cytochrome c oxidase copper chaperone |
| UniProt Protein Name: | Cytochrome c oxidase copper chaperone |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cytochrome c oxidase copper chaperone |
| UniProt Gene Name: | COX17Â Â |
| UniProt Entry Name: | COX17_HUMAN |
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