CNOT9 Antibody (PACO38898)
- SKU:
- PACO38898
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CNOT9 Antibody (PACO38898)
The CNOT9 Polyclonal Antibody (PACO38898) is a valuable tool for researchers studying CNOT9, a protein involved in gene regulation and RNA processing. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in various research applications such as Western blotting.CNOT9 is a component of the CCR4-NOT complex, which plays a crucial role in mRNA degradation and transcriptional regulation in eukaryotic cells. Dysregulation of CNOT9 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance in cellular homeostasis.
By using the CNOT9 Polyclonal Antibody, researchers can detect and analyze the expression of CNOT9 in different cell types, providing valuable insights into its functions and potential therapeutic applications. This antibody is a valuable tool for studies in molecular biology, cancer research, and neurobiology, helping to advance our understanding of CNOT9's role in health and disease.
| Antibody Name: | CNOT9 Antibody (PACO38898) |
| Antibody SKU: | PACO38898 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CNOT9 antibody at 6µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: Mouse small intestine tissue. Lane 3: Mouse spleen tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 34, 37, 30 kDa. Observed band size: 34 kDa. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38898 at dilution of 1:100. |
| Background: | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Synonyms: | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1), CNOT9, RCD1 RQCD1 |
| UniProt Protein Function: | RQCD1: Transcription factor that down-regulates MYB- and JUN- dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. Belongs to the RCD1 family.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 2q35Cellular Component: CCR4-NOT complex; cytosol; membraneMolecular Function: protein binding; protein domain specific binding; protein homodimerization activityBiological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of estrogen receptor signaling pathway; negative regulation of translation; poly(A) tail shortening; sex differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q92600 |
| NCBI GenInfo Identifier: | 74716599 |
| NCBI Gene ID: | 9125 |
| NCBI Accession: | Q92600.1 |
| UniProt Secondary Accession: | Q92600,Q96IX4, B2RPI0, B5MDQ4, B7Z1E5 |
| UniProt Related Accession: | Q92600 |
| Molecular Weight: | 29,140 Da |
| NCBI Full Name: | Cell differentiation protein RCD1 homolog |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex subunit 9 |
| NCBI Official Symbol: | CNOT9Â Â |
| NCBI Official Synonym Symbols: | RCD1; CAF40; CT129; RCD-1; RQCD1Â Â |
| NCBI Protein Information: | cell differentiation protein RCD1 homolog |
| UniProt Protein Name: | Cell differentiation protein RCD1 homolog |
| UniProt Synonym Protein Names: | CCR4-NOT transcription complex subunit 9 |
| Protein Family: | Cell differentiation protein |
| UniProt Gene Name: | RQCD1Â Â |
| UniProt Entry Name: | RCD1_HUMAN |
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