The CNIH3 Polyclonal Antibody (PACO39466) is a valuable tool for research involving the CNIH3 protein, a member of the cornichon family that plays a crucial role in the regulation of AMPA receptor trafficking and function. This antibody, produced in rabbits, is highly specific for detecting CNIH3 in human samples and has been validated for use in various applications, including Western blotting.CNIH3 is known to modulate the surface expression of AMPA receptors, which are essential for synaptic transmission and plasticity in the brain.
Dysregulation of CNIH3 has been implicated in neurological disorders such as epilepsy and schizophrenia, making it a promising target for further study in neuroscience research.By using the CNIH3 Polyclonal Antibody, researchers can accurately detect and analyze CNIH3 levels in different cell types, helping to deepen our understanding of its role in synaptic transmission and potentially leading to the development of novel therapeutic strategies for neurological conditions.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO39466 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO39466 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human brain tissue using PACO39466 at dilution of 1:100.
Background:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.
Synonyms:
Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3), CNIH3
UniProt Protein Function:
CNIH3: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Belongs to the cornichon family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1q42.12Cellular Component: dendritic shaft; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; postsynaptic membraneBiological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport
