The CMTR2 Polyclonal Antibody (PAC037750) is a valuable tool for researchers studying CMTR2, a protein involved in mRNA cap guanine-N7 methylation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CMTR2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for investigations in molecular biology and RNA processing.CMTR2 is a key player in RNA modification processes, particularly in mRNA capping, which is essential for gene expression regulation and proper mRNA translation.
Dysregulation of CMTR2 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. Understanding the function and regulation of CMTR2 is crucial for advancing our knowledge of gene expression mechanisms and developing targeted treatments for related diseases.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO37750 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO37750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.
