The CLUAP1 Polyclonal Antibody (PACO08475) is a valuable tool for researchers studying CLUAP1, a key protein involved in ciliogenesis and ciliary function. This antibody, developed using rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications.CLUAP1, also known as Clusterin-Associated Protein 1, is essential for the formation and maintenance of cilia, hair-like structures found on the surface of many cell types. Dysregulation of ciliary function has been implicated in a range of human diseases, including developmental disorders and ciliopathies.
By targeting CLUAP1 with this antibody, researchers can accurately detect and study the protein's role in ciliary biology, providing insights into potential therapeutic approaches for cilia-related conditions. The CLUAP1 Polyclonal Antibody is a valuable tool for investigating the functions of CLUAP1 in various biological processes, making it a valuable addition to studies on cilia-related diseases, developmental biology, and ciliogenesis research.
clusterin associated protein 1;CLUAP1;FLJ13297;KIAA0643 ;
UniProt Protein Function:
CLUAP1: a nuclear protein commonly upregulated in colon cancers. It encodes a nuclear protein of 413 amino acids containing a coiled-coil domain. Associated with nuclear clusterin in a yeast two-hybrid system. Its expression gradually increases in the late S to G2/M phases of cell cycle and it returns to the basal level in the G0/G1 phases. RNAi suppression of this gene resulted in growth retardation in the transfected cells. Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: centrosome; cilium; intracellular membrane-bound organelle; nucleoplasmMolecular Function: protein bindingBiological Process: cilium biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
