CLEC4M Rabbit Polyclonal Antibody (CAB14268)
- SKU:
- CAB14268
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | CLEC4M Rabbit Polyclonal Antibody |
SKU: | CAB14268 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 71-399 of human CLEC4M (NP_055072.3). |
Sequence: | QVSK VPSS LSQE QSEQ DAIY QNLT QLKA AVGE LSEK SKLQ EIYQ ELTQ LKAA VGEL PEKS KLQE IYQE LTRL KAAV GELP EKSK LQEI YQEL TRLK AAVG ELPE KSKL QEIY QELT RLKA AVGE LPEK SKLQ EIYQ ELTE LKAA VGEL PEKS KLQE IYQE LTQL KAAV GELP DQSK QQQI YQEL TDLK TAFE RLCR HCPK DWTF FQGN CYFM SNSQ RNWH DSVT ACQE VRAQ LVVI KTAE EQNF LQLQ TSRS NRFS WMGL SDLN QEGT WQWV DGSP LSPS FQRY WNSG EPNN SGNE DCAE FSGS GWND NRCD VDNY WICK KPAA CFRD E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR; CLEC4M |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type II membrane protein. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection.
Purification Method: | Affinity purification |
Gene ID: | 10332 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |