The CHST13 Polyclonal Antibody (PAC013403) is a valuable tool for researchers studying CHST13, a key enzyme involved in the biosynthesis of chondroitin sulfate. This rabbit polyclonal antibody is highly specific to human samples and is validated for use in applications such as Western blotting. By targeting the CHST13 protein, this antibody allows for the detection and analysis of CHST13 in various cell types, making it ideal for studies in glycobiology and cartilage research.CHST13, also known as chondroitin 4-sulfotransferase 2, plays a crucial role in the modification of chondroitin sulfate, a major component of the extracellular matrix.
Understanding the function of CHST13 is essential for unraveling the complex processes involved in cartilage development and maintenance. Research on CHST13 may also have implications for diseases such as osteoarthritis and cancer, where abnormalities in chondroitin sulfate metabolism have been observed.By using the CHST13 Polyclonal Antibody, researchers can gain valuable insights into the role of CHST13 in various biological processes and diseases, ultimately contributing to the development of targeted therapies and interventions in the field of glycobiology and musculoskeletal disorders.
CHST13: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. Belongs to the sulfotransferase 2 family.Protein type: EC 2.8.2.5; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Energy Metabolism - sulfurChromosomal Location of Human Ortholog: 3q21.3Cellular Component: Golgi membrane; integral to membraneMolecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: carbohydrate biosynthetic process; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; chondroitin sulfate metabolic process; glycosaminoglycan metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
