The CHML Antibody (PAC023470) is a polyclonal antibody designed for research involving CHML, a protein involved in cellular processes and immune regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the CHML protein, this antibody enables researchers to detect and analyze CHML expression in various cell types, making it an ideal tool for studies in immunology and cancer research.CHML, also known as Choroideremia-like protein, plays a crucial role in cellular function and immune regulation. Its involvement in immune response modulation highlights its importance as a target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function of CHML is essential for developing therapies that can manipulate immune responses in these disease contexts.Overall, the CHML Antibody (PAC023470) serves as a valuable tool for researchers investigating the role of CHML in immune regulation and disease pathogenesis. Its specificity and reliability make it an essential component for studies aiming to decipher the intricate mechanisms underlying immune responses and disease development.
Synthesized peptide derived from internal of human CHML.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using CHML antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHML antibody.
Background:
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Synonyms:
Rab proteins geranylgeranyltransferase component A 2; Rab escort protein 2; REP-2; Choroideraemia-like protein;
UniProt Protein Function:
CHML: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. Belongs to the Rab GDI family.Chromosomal Location of Human Ortholog: 1q43Cellular Component: cytoplasm; nucleoplasm; Rab-protein geranylgeranyltransferase complexMolecular Function: Rab GTPase bindingBiological Process: protein geranylgeranylation
UniProt Protein Details:
NCBI Summary:
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
