The CES1 Polyclonal Antibody (CAB1853) is a valuable tool for researchers studying Carboxylesterase 1 (CES1), a critical enzyme involved in drug metabolism and lipid homeostasis. This antibody, developed through rabbit immunization, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By specifically binding to CES1 protein, this antibody enables precise detection and analysis in different cell types, making it an essential component for studies in pharmacology, toxicology, and lipid metabolism research.CES1, a key member of the carboxylesterase family, plays a vital role in the metabolism of a wide range of therapeutic drugs, environmental chemicals, and lipid substrates.
Its involvement in drug activation and deactivation processes highlights its significance in drug efficacy and toxicity studies. Furthermore, CES1 dysregulation has been associated with various human diseases, making it a potential target for therapeutic interventions.By utilizing the CES1 Polyclonal Antibody, researchers can gain valuable insights into the functions and regulatory mechanisms of CES1, paving the way for the development of novel therapeutic strategies targeting drug metabolism and lipid metabolism pathways. Understanding the role of CES1 in health and disease is crucial for advancing precision medicine and improving patient outcomes in various clinical settings.
Product Name:
CES1 Rabbit Polyclonal Antibody
SKU:
CAB1853
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 287-566 of human CES1 (NP_001257.4).
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1066
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CES1 Rabbit pAb (CAB1853) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
