Anti-CERS4 Antibody (PACO19927)

Antibody Name:	CERS4 Antibody (PACO19927)
Antibody SKU:	PACO19927
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human CERS4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19927(CERS4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19927(CERS4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid, endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.

Synonyms:

ceramide synthase 4

UniProt Protein Function:	Lass4: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.Protein type: Membrane protein, multi-pass; Membrane protein, integral; DNA-bindingChromosomal Location of Human Ortholog: 19p13.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membraneMolecular Function: sphingosine N-acyltransferase activityBiological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q9HA82
NCBI GenInfo Identifier:	296434561
NCBI Gene ID:	79603
NCBI Accession:	Q9HA82.2
UniProt Secondary Accession:	Q9HA82,D6W665
UniProt Related Accession:	Q9HA82
Molecular Weight:	46,399 Da
NCBI Full Name:	Ceramide synthase 4
NCBI Synonym Full Names:	ceramide synthase 4
NCBI Official Symbol:	CERS4
NCBI Official Synonym Symbols:	Trh1; LASS4
NCBI Protein Information:	ceramide synthase 4
UniProt Protein Name:	Ceramide synthase 4
UniProt Synonym Protein Names:	LAG1 longevity assurance homolog 4
Protein Family:	Ceramide synthase
UniProt Gene Name:	CERS4
UniProt Entry Name:	CERS4_HUMAN

Antibodies

CERS4 Antibody (PACO01014)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)