The CEP76 Polyclonal Antibody (PACO22255) is a versatile tool for researchers studying CEP76, a key protein involved in cell division and DNA repair processes. This antibody, produced in rabbits, displays high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CEP76 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in molecular biology and cancer research.CEP76, also known as centrosomal protein of 76 kDa, is a crucial player in ensuring accurate chromosome segregation and maintaining genomic stability during cell division.
Dysregulation of CEP76 has been linked to chromosomal instability and tumorigenesis, highlighting its importance in understanding cancer development and progression. By investigating the role of CEP76 in cell cycle control and DNA repair mechanisms, researchers can gain valuable insights into potential therapeutic targets for cancer treatment and intervention strategies.
Antibody Name:
CEP76 Antibody (PACO22255)
Antibody SKU:
PACO22255
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CEP76.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 3T3 cells, using CEP76 antibody.
Background:
Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
Synonyms:
C18orf9; centrosomal protein 76kDa; HsT1705;
UniProt Protein Function:
CEP76: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. Belongs to the CEP76 family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18p11.21Cellular Component: centriole; centrosome; cytosol; protein complexMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; organelle organization and biogenesis; regulation of centriole replication
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
