The CEP72 Polyclonal Antibody (PACO08370) is a valuable tool for researchers studying CEP72, a centrosomal protein involved in cell division and ciliogenesis. This antibody, developed using rabbit immunization techniques, is highly specific to human CEP72 protein and has been validated for Western blot applications. Its ability to detect CEP72 expression in various cell types makes it a versatile tool for research in cell biology, developmental biology, and cancer biology.
CEP72 is essential for centrosome function and spindle assembly during cell division, making it a key player in maintaining genomic stability. Dysregulation of CEP72 has been associated with various diseases, including cancer, ciliopathies, and developmental disorders. By studying the expression and function of CEP72 using this antibody, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.
centrosomal protein 72kDa;CEP72;FLJ10565;KIAA1519;MGC5307 ;
UniProt Protein Function:
CEP72: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Belongs to the CEP72 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Microtubule-bindingChromosomal Location of Human Ortholog: 5p15.33Cellular Component: centrosome; cytosolMolecular Function: protein bindingBiological Process: centriole replication; G2/M transition of mitotic cell cycle; gamma-tubulin complex localization; spindle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
