The CENPU Monoclonal Antibody (PAC010508) offered by Assay Genie is a valuable tool for researchers studying the centromere protein C (CENPU). This antibody, produced in a monoclonal format, specifically targets the CENPU protein, which plays a crucial role in centromere function and chromosome segregation during cell division.Validated for use in various applications, including Western blot and immunofluorescence, this antibody is highly reactive with human samples, making it an ideal choice for studying CENPU in different cell types and tissues. By binding to the CENPU protein, researchers can effectively detect and analyze its expression levels, localization, and interactions, providing valuable insights into its function in cell division and genomic stability.
Given the importance of CENPU in maintaining chromosome integrity and proper cell division, research using this antibody has implications for understanding cell cycle regulation, genome stability, and the development of targeted therapies for diseases related to aberrant chromosome segregation. With its high specificity and sensitivity, the CENPU Monoclonal Antibody is a reliable tool for advancing research in molecular biology, genetics, and cancer biology.
CENPU: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 4q35.1Cellular Component: cytosol; microtubule organizing center; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: DNA replication-independent nucleosome assembly at centromere; sister chromatid cohesion
UniProt Protein Details:
NCBI Summary:
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Centromere protein of 50 kDa; CENP-50; Interphase centromere complex protein 24; KSHV latent nuclear antigen-interacting protein 1; MLF1-interacting protein; Polo-box-interacting protein 1
