The CDC42EP5 Polyclonal Antibody (PACO00570) is a powerful tool for researchers studying CDC42EP5, a protein involved in cell signaling and regulation of cellular processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot experiments.CDC42EP5, also known as CDC42 effector protein 5, is a key player in the CDC42 signaling pathway, which is responsible for cell migration, cell polarity, and cytoskeletal organization. By targeting CDC42EP5, researchers can gain a better understanding of these biological processes and their implications in various diseases, including cancer and neurological disorders.
With its ability to detect CDC42EP5 in different cell types, the PACO00570 antibody is an invaluable tool for studies in cell biology, biochemistry, and drug discovery. By uncovering the role of CDC42EP5 in cellular function, researchers can potentially identify new therapeutic targets and interventions for a range of health conditions.
Antibody Name:
CDC42EP5 Antibody
Antibody SKU:
PACO00570
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the N-terminal region of human Cdc42EP5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CDC42EP5; BORG3; CEP5; Cdc42 effector protein 5; Binder of Rho GTPases 3
UniProt Protein Function:
CDC42EP5: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. Belongs to the BORG/CEP family.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: cytoskeleton; membrane; cytoplasm; plasma membrane; endomembrane systemMolecular Function: GTP-Rho bindingBiological Process: regulation of cell shape; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; JNK cascade; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
