CDC42 Rabbit Polyclonal Antibody (CAB15657)
- SKU:
- CAB15657
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | CDC42 Rabbit Polyclonal Antibody |
SKU: | CAB15657 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human CDC42 (NP_001782.1). |
Sequence: | MQTI KCVV VGDG AVGK TCLL ISYT TNKF PSEY VPTV FDNY AVTV MIGG EPYT LGLF DTAG QEDY DRLR PLSY PQTD VFLV CFSV VSPS SFEN VKEK WVPE ITHH CPKT PFLL VGTQ IDLR DDPS TIEK LAKN KQKP ITPE TAEK LARD LKAV KYVE CSAL TQKG LKNV FDEA ILAA LEPP EPKK SR |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | TKS; G25K; CDC42Hs; CDC42 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor, Midbody, centrosome, cytoskeleton, microtubule organizing center, spindle. |
Calculated MW: | 21kDa |
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
Purification Method: | Affinity purification |
Gene ID: | 998 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |