CD207 Rabbit Polyclonal Antibody (CAB6553)
- SKU:
- CAB6553
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CD207 Rabbit Polyclonal Antibody |
SKU: | CAB6553 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-200 of human Langerin/CD207 (NP_056532.4). |
Sequence: | TISD VKTN VQLL KGRV DNIS TLDS EIKK NSDG MEAA GVQI QMVN ESLG YVRS QFLK LKTS VEKA NAQI QILT RSWE EVST LNAQ IPEL KSDL EKAS ALNT KIRA LQGS LENM SKLL KRQN DILQ VVSQ GWK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CLEC4K; Langerin/CD207 |
Positive Sample: | A-549,A-431,Jurkat,Mouse lung,Rat lung,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type II membrane protein. |
Calculated MW: | 37kDa |
Observed MW: | 40-50kDa |
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
Purification Method: | Affinity purification |
Gene ID: | 50489 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |