The CD207 Monoclonal Antibody (PAC052594) is a valuable tool for researchers studying CD207, a cell surface protein involved in antigen presentation and immune response regulation. This antibody, developed using monoclonal technology, shows high specificity and sensitivity towards human CD207 and is suitable for various immunoassays, including Western blotting and immunohistochemistry.CD207, also known as Langerin, is primarily expressed on Langerhans cells in the skin and dendritic cells in mucosal tissues. It plays a crucial role in capturing and processing antigens for immune activation and tolerance.
Researchers studying skin disorders, infectious diseases, and immune responses in mucosal tissues can benefit from using this antibody to detect and analyze CD207 expression in different cell types and tissues.By targeting CD207 with this monoclonal antibody, researchers can gain insights into the role of Langerhans cells and dendritic cells in antigen presentation, immune regulation, and disease pathogenesis. This antibody opens up opportunities for investigating novel therapeutic strategies for conditions involving aberrant immune responses and antigen presentation pathways.
Antibody Name:
Cd207 Antibody (PACO52594)
Antibody SKU:
PACO52594
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse C-type lectin domain family 4 member K protein (63-331AA)
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.
Synonyms:
C-type lectin domain family 4 member K (Langerin) (CD antigen CD207), Cd207, Clec4k
UniProt Protein Function:
langerin: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Homotrimer. Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 6|6 C3Cellular Component: integral to plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to virus
