The CD1a Monoclonal Antibody (PAC044115) is a valuable tool for researchers studying CD1a, a cell surface protein involved in antigen presentation and immune response modulation. This antibody, produced using hybridoma technology, is specifically designed for use in various immunoassays, including flow cytometry and immunohistochemistry.CD1a is a member of the CD1 family of glycoproteins, which play a crucial role in presenting lipid antigens to T cells. CD1a is predominantly expressed on dendritic cells and thymocytes, where it helps initiate immune responses against foreign pathogens.
The CD1a Monoclonal Antibody binds specifically to CD1a, allowing for the detection and analysis of this protein in different cell types and tissues.Research involving CD1a is important for understanding the mechanisms underlying immune responses and the development of potential immunotherapies for diseases such as cancer, infectious diseases, and autoimmune disorders. The CD1a Monoclonal Antibody offers researchers a reliable and specific tool for investigating the role of CD1a in these contexts, making it a valuable asset for immunology and cancer research.
Recombinant Human T-cell surface glycoprotein CD1a protein (21-181AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: CD1A antibody at 6µg/ml. Lane 1: K562 whole cell lysate. Lane 2: Mouse thymus tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa..
Immunohistochemistry of paraffin-embedded human skin tissue using PACO44115 at dilution of 1: 100.
Background:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
