The CD1a Polyclonal Antibody (PAC044114) is a valuable tool for researchers studying CD1a, a cell surface molecule involved in presenting lipid antigens to T cells. This antibody, produced in rabbits, has high reactivity with human samples and is optimized for use in various applications, including immunofluorescence and flow cytometry. By binding specifically to CD1a, researchers can accurately detect and analyze this protein in different cell types, making it essential for studies in immunology and infectious disease research.
CD1a plays a crucial role in immune responses by presenting lipid antigens to T cells, enabling the immune system to recognize and respond to foreign invaders. Its function in antigen presentation makes it a target of interest for researchers studying diseases such as infectious diseases, cancer, and autoimmune disorders. Understanding the role of CD1a in immune responses is essential for developing new diagnostic tools and therapeutic strategies to combat these diseases effectively.
Antibody Name:
CD1A Antibody (PACO44114)
Antibody SKU:
PACO44114
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human T-cell surface glycoprotein CD1a protein (21-181AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human skin tissue using PACO44114 at dilution of 1:100.
Background:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
