The CD1a Antibody (PAC015963) is a high-quality polyclonal antibody designed for research involving the CD1a cell surface molecule. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the CD1a protein, this antibody enables detection and analysis in different cell types, making it an ideal tool for studies in immunology and cancer research.CD1a is a cell surface antigen that plays a crucial role in antigen presentation and immune response regulation.
It is involved in T cell activation and has been implicated in various diseases, including cancer and autoimmune disorders. Understanding the function of CD1a is essential for developing targeted therapies and exploring its potential as a biomarker for disease diagnosis and prognosis.Overall, the CD1a Antibody (PAC015963) offers researchers a reliable tool for studying CD1a and its role in immune regulation and disease development. Its high reactivity and specificity make it a valuable asset in the field of immunology and cancer research.
Antibody Name:
CD1A Antibody (PACO15963)
Antibody SKU:
PACO15963
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Fusion protein of human CD1A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: PACO15963(CD1A Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Synonyms:
CD1a molecule
UniProt Protein Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]