The CARF Antibody (PAC023380) is a polyclonal antibody designed for research involving the CARF protein, a key regulator of cellular activities implicated in cancer progression and immune response modulation. Raised in rabbits, this antibody shows high reactivity with human samples and is validated for use in various applications such as Western blotting. By binding specifically to the CARF protein, it enables researchers to detect and analyze CARF expression in different cell types, making it ideal for studies in cancer biology and immunology.
CARF, also known as cell cycle and apoptosis regulator protein, plays a critical role in controlling cell proliferation, apoptosis, and differentiation, making it a potential target for cancer therapy and immunomodulation. Its involvement in regulating key cellular processes underscores its importance in understanding cancer development and immune response modulation. Research into CARF may lead to the development of novel therapeutic strategies for treating cancer and immune-related disorders.
Synthesized peptide derived from internal of human ALS2CR8.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, using ALS2CR8 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using ALS2CR8 antibody.
Background:
Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.
Synonyms:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24;
UniProt Protein Function:
CARF: May be a transcription factor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: 2q33.2Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity
