The CAPS2 Polyclonal Antibody (PAC057436) is a valuable tool for researchers studying the CAPS2 protein, which plays a key role in regulating neurotransmitter release in the brain. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.CAPS2, also known as Calcium-dependent activator protein for secretion 2, is involved in the release of neurotransmitters such as serotonin and dopamine, impacting synaptic communication and neuronal signaling. Research on CAPS2 is crucial for understanding its role in synaptic transmission and its potential implications in neurological disorders such as depression and schizophrenia.
By targeting CAPS2 with this specific antibody, researchers can effectively detect and analyze the protein in different cell types, providing insights into its functions and potential therapeutic implications. This antibody is a valuable tool for studies in neuroscience, pharmacology, and drug development, offering new avenues for exploring the intricacies of neurotransmitter release mechanisms in the brain.
Western Blot. Positive WB detected in: PC-3 whole cell lysate, Colo320 whole cell lysate. All lanes: CAPS2 antibody at 5.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64, 45, 34 kDa. Observed band size: 45 kDa.
IHC image of PACO57436 diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO57436 diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
calcium ion binding, calcium:sodium antiporter activity, calcium ion homeostasis
Synonyms:
Calcyphosin-2 (Calcyphosine-2), CAPS2
UniProt Protein Function:
CAPS2: 3 isoforms of the human protein are produced by alternative splicingProtein type: Calcium-bindingChromosomal Location of Human Ortholog: 12q14.1Molecular Function: calcium ion binding
UniProt Protein Details:
NCBI Summary:
Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]
