The CALR3 Polyclonal Antibody (PACO08151) is a valuable tool for research involving CALR3, a protein involved in calcium homeostasis and cell signaling. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By binding to the CALR3 protein, this antibody enables researchers to detect and analyze CALR3 expression in different cell types, making it ideal for studies in cell biology and signal transduction.CALR3 is a member of the calreticulin family of proteins and has been implicated in various cellular processes, including protein folding and calcium storage.
Its role in regulating intracellular calcium levels and modulating signaling pathways makes it a promising target for research in areas such as cancer biology and neurodegenerative diseases. Understanding the functions of CALR3 may provide insights into disease mechanisms and lead to the development of novel therapeutic strategies targeting this protein.
calreticulin 3: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19). CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the calreticulin family.Protein type: Chaperone; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: endoplasmic reticulum lumenMolecular Function: unfolded protein binding; calcium ion binding; carbohydrate bindingBiological Process: protein folding; spermatogenesis; cell differentiationDisease: Cardiomyopathy, Familial Hypertrophic, 19
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
