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CACNG8 Antibody (PACO63447)

SKU:
PACO63447
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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CACNG8 Antibody (PACO63447)

The CACNG8 Polyclonal Antibody (PAC063447) is a valuable tool for researchers studying the CACNG8 protein, which is a critical component of voltage-gated calcium channels in the brain. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CACNG8 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for neuroscience and neurology research.CACNG8 is known for its role in regulating calcium influx into neurons, which is crucial for synaptic transmission and neuronal excitability.

Dysregulation of CACNG8 has been implicated in neurological disorders such as epilepsy, Alzheimer's disease, and schizophrenia, making it a promising target for drug development and therapeutic interventions. By studying the function and expression of CACNG8 using this antibody, researchers can gain valuable insights into the mechanisms underlying these debilitating conditions and potentially identify novel treatment strategies.

Antibody Name:CACNG8 Antibody (PACO63447)
Antibody SKU:PACO63447
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:Human
Immunogen:Peptide sequence from Human Voltage-dependent calcium channel gamma-8 subunit protein (65-83AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO63447 diluted at 1:700 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Synonyms:Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8), CACNG8, CACNG6
UniProt Protein Function:CACNG8: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calciumChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membrane; postsynaptic densityMolecular Function: channel regulator activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]
UniProt Code:Q8WXS5
NCBI GenInfo Identifier:313104245
NCBI Gene ID:59283
NCBI Accession:Q8WXS5.3
UniProt Secondary Accession:Q8WXS5,Q9BXT0, Q9BY23
UniProt Related Accession:Q8WXS5
Molecular Weight:43,313 Da
NCBI Full Name:Voltage-dependent calcium channel gamma-8 subunit
NCBI Synonym Full Names:calcium voltage-gated channel auxiliary subunit gamma 8
NCBI Official Symbol:CACNG8  
NCBI Official Synonym Symbols:
NCBI Protein Information:voltage-dependent calcium channel gamma-8 subunit
UniProt Protein Name:Voltage-dependent calcium channel gamma-8 subunit
UniProt Synonym Protein Names:Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8; TARP gamma-8
Protein Family:Voltage-dependent calcium channel
UniProt Gene Name:CACNG8  
UniProt Entry Name:CCG8_HUMAN
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