CACNA1G Antibody (PACO19378)
- SKU:
- PACO19378
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CACNA1G Antibody (PACO19378)
The CACNA1G Monoclonal Antibody (PACO19378) is a valuable tool for researchers studying the CACNA1G protein, which is involved in calcium channel activity and neurological function. This antibody, produced through a specific monoclonal hybridization process, is highly specific to human and mouse samples and is recommended for use in immunofluorescence and immunohistochemistry applications. The CACNA1G protein, also known as T-type calcium channel Cav3.1, plays a crucial role in neuronal excitability and synaptic transmission. Dysregulation of CACNA1G has been linked to neurological disorders such as epilepsy, autism, and neurodegenerative diseases.
By targeting the CACNA1G protein, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify novel therapeutic targets.This antibody offers researchers a reliable tool for studying the expression and localization of CACNA1G in various tissues and cell types, making it ideal for investigations into neurobiology, pharmacology, and disease pathology. The specificity and sensitivity of this monoclonal antibody make it a valuable asset for advancing our understanding of calcium channel biology and its implications for human health.
| Antibody Name: | CACNA1G Antibody (PACO19378) |
| Antibody SKU: | PACO19378 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Synthetic peptide of human CACNA1G |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19378(CACNA1G Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19378(CACNA1G Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and γ subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. |
| Synonyms: | calcium channel, voltage-dependent, T type, α 1G subunit |
| UniProt Protein Function: | Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion.Post-translational modification: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. [View classification] |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O43497 |
| NCBI GenInfo Identifier: | 34783701 |
| NCBI Gene ID: | 12291 |
| NCBI Accession: | AAH57399 |
| UniProt Secondary Accession: | O43497 |
| UniProt Related Accession: | O43497 |
| Molecular Weight: | |
| NCBI Full Name: | Cacna1g protein |
| NCBI Synonym Full Names: | calcium channel, voltage-dependent, T type, alpha 1G subunit |
| NCBI Official Symbol: | Cacna1g  |
| NCBI Official Synonym Symbols: | a1G; [a]1G; Cav3.1d; alpha-1G; mKIAA1123Â Â |
| NCBI Protein Information: | voltage-dependent T-type calcium channel subunit alpha-1G |
| UniProt Protein Name: | Voltage-dependent T-type calcium channel subunit alpha-1G |
| UniProt Synonym Protein Names: | Cav3.1c; NBR13; Voltage-gated calcium channel subunit alpha Cav3.1 |
| Protein Family: | |
| UniProt Gene Name: | CACNA1GÂ Â |
| UniProt Entry Name: | CAC1G_HUMAN |
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