The BTN2A2 Monoclonal Antibody (PACO08061) is a valuable tool for researchers studying the BTN2A2 protein, which is involved in immune regulation and cell-cell interactions. This antibody, developed using advanced technology, is highly specific to BTN2A2 and is validated for use in various applications such as immunofluorescence and flow cytometry.BTN2A2 is a member of the Butyrophilin family, known for its role in immune modulation and T cell activation. Research suggests that BTN2A2 plays a crucial role in promoting immune tolerance and regulating T cell responses, making it a promising target for studies on immune-mediated diseases and cancer.
By using the BTN2A2 Monoclonal Antibody (PACO08061), researchers can effectively detect and study the expression and function of BTN2A2 in different cell types and tissues. This antibody opens up opportunities for further investigation into the mechanisms underlying immune regulation and offers insights into potential therapeutic strategies for immune-related disorders.
butyrophilin, subfamily 2, member A2;BTN2A2;BT2.2;BTF2;FLJ41908 ;
UniProt Protein Function:
BTN2A2: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p22.2Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of activated T cell proliferation; negative regulation of cellular metabolic process; negative regulation of cytokine secretion
UniProt Protein Details:
NCBI Summary:
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
