BRCA1 Rabbit Polyclonal Antibody (CAB11318)
- SKU:
- CAB11318
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | BRCA1 Rabbit Polyclonal Antibody |
SKU: | CAB11318 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-699 of human BRCA1 (NP_009225.1). |
Sequence: | DGES ESNA KVAD VLDV LNEV DEYS GSSE KIDL LASD PHEA LICK SERV HSKS VESN IEDK IFGK TYRK KASL PNLS HVTE NLII GAFV TEPQ IIQE RPLT NKLK RKRR PTSG LHPE DFIK KADL AVQK TPEM INQG TNQT EQNG QVMN ITNS GHEN KTKG DSIQ NEKN PNPI ESLE KESA FKTK AEPI SSSI SNME LELN IHNS KAPK KNRL RRKS STRH IHAL ELVV SRNL SPPN CTEL QIDS CSSS EEIK KKKY NQMP VRHS RNLQ LMEG KEPA TGAK KSNK PNEQ TSKR HDSD TFPE |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; BRCA1 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Cytoplasm, Cytoplasm, Nucleus. |
Calculated MW: | 208kDa |
Observed MW: | Refer to figures |
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Purification Method: | Affinity purification |
Gene ID: | 672 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |