The BRCA1 Polyclonal Antibody (CAB11318) is a specialized tool for researchers studying the BRCA1 gene, which is known for its role in DNA repair and maintenance of genomic stability. This antibody, developed using rabbit immunization, exhibits high specificity for human samples and has been validated for Western blot applications.BRCA1 is a tumor suppressor gene that, when mutated, can increase the risk of breast and ovarian cancer. The BRCA1 Polyclonal Antibody binds to the BRCA1 protein, enabling researchers to detect and analyze its expression in various cell types.
This makes it ideal for studies in cancer biology and genomics.Due to its importance in DNA repair mechanisms, understanding the function of BRCA1 is crucial for developing targeted therapies for cancer treatment. The BRCA1 Polyclonal Antibody provides researchers with a valuable tool to investigate the role of BRCA1 in cancer development and progression, ultimately contributing to advancements in personalized medicine and treatment strategies for patients with BRCA1 mutations.
Product Name:
BRCA1 Rabbit Polyclonal Antibody
SKU:
CAB11318
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-699 of human BRCA1 (NP_009225.1).
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Purification Method:
Affinity purification
Gene ID:
672
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using BRCA1 Rabbit pAb (CAB11318) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
