The BMPR2 Polyclonal Antibody (CAB16232) is specially designed for research involving BMPR2, a cell surface receptor that plays a key role in the regulation of cell growth and differentiation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it a valuable tool for Western blot applications. By binding specifically to BMPR2 protein, this antibody allows for the detection and analysis of BMPR2 expression in various cell types, making it an ideal choice for studies in developmental biology and cancer research.BMPR2, also known as bone morphogenetic protein receptor type II, is crucial for mediating the effects of bone morphogenetic proteins (BMPs) on cell proliferation and differentiation.
Dysregulation of BMPR2 signaling has been implicated in various diseases, including pulmonary arterial hypertension and cancer. By understanding the function of BMPR2, researchers can gain insights into the mechanisms underlying these diseases and potentially identify therapeutic targets for treatment. The BMPR2 Polyclonal Antibody (CAB16232) is a valuable tool for investigating the role of BMPR2 in various biological processes and disease states.
Product Name:
BMPR2 Rabbit Polyclonal Antibody
SKU:
CAB16232
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 739-1038 of human BMPR2 (NP_001195.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
115kDa
Observed MW:
115kDa
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Purification Method:
Affinity purification
Gene ID:
659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BMPR2 Rabbit pAb (CAB16232) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
