The Biotinylated Anti-CD40 Antibody (HDLA064) offered by Assay Genie is a valuable tool for research involving CD40, a cell surface receptor that plays a critical role in immune response regulation. This antibody, created specifically for use in immunology and cancer research, is highly reactive with human samples and has been validated for use in various applications, including Western blot.CD40 is known for its involvement in activating immune cells and promoting inflammation, making it an important target for studies related to infectious diseases, autoimmune disorders, and cancer.
By binding to the CD40 protein, this antibody enables accurate detection and analysis in different cell types, providing researchers with valuable insights into the mechanisms underlying immune response modulation.With its ability to support research into diseases characterized by dysregulated immune responses, the Biotinylated Anti-CD40 Antibody (HDLA064) is a valuable resource for scientists seeking to better understand and potentially target CD40-related pathways for therapeutic intervention.
SKU:
HDLA064
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM102
Synonyms:
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
