The BCL10 Rabbit Monoclonal Antibody (CAB4520) is a powerful tool for researchers studying BCL10, a protein involved in the regulation of cell survival and apoptosis. This antibody, produced using cutting-edge technology in rabbit monoclonal antibody production, exhibits high specificity and sensitivity for detecting BCL10 in human samples. Validated for use in Western blot applications, this antibody binds specifically to the BCL10 protein, allowing for accurate detection and analysis in a variety of cell types.BCL10 is a key player in cell signaling pathways that control cell growth, differentiation, and apoptosis.
Dysregulation of BCL10 has been linked to various diseases, including cancer and autoimmune disorders. By targeting BCL10 and investigating its function, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.With its superior performance and versatility, the BCL10 Rabbit Monoclonal Antibody (CAB4520) is an essential tool for studies in immunology, cancer research, and apoptosis regulation. Its reliability and precision make it an invaluable asset for research projects seeking to unravel the intricacies of BCL10-mediated cellular processes.
Product Name:
Bcl10 Rabbit Monoclonal Antibody
SKU:
CAB4520
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human Bcl10 (O95999).
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8915
Clone Number:
ARC2673
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Bcl10 Rabbit mAb (CAB4520) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
