The BAZ1B Polyclonal Antibody (PAC020927) is a valuable tool for researchers studying the BAZ1B protein, a key player in chromatin remodeling and gene regulation. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting BAZ1B in human samples, making it ideal for use in Western blot applications. By targeting the BAZ1B protein, this antibody enables precise detection and analysis of BAZ1B in various cell types, offering valuable insights into its role in cellular processes.BAZ1B, also known as Williams syndrome transcription factor, is known for its involvement in chromatin remodeling and transcriptional regulation, making it a crucial protein in gene expression control.
Its implications in various biological processes, such as DNA repair and cell cycle regulation, make it an attractive target for research in fields like epigenetics and developmental biology. By understanding the functions of BAZ1B, researchers can gain valuable information that may lead to advancements in therapeutic interventions targeting diseases related to chromatin remodeling dysregulation.
Antibody Name:
BAZ1B Antibody (PACO20927)
Antibody SKU:
PACO20927
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human BAZ1B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20927(BAZ1B Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
Synonyms:
bromodomain adjacent to zinc finger domain, 1B
UniProt Protein Function:
WSTF: plays a central role in chromatin remodeling and acts as a transcription regulator. Apparently possesses tyrosine-protein kinase activity, but bears no sequence resemblance classical tyrosine kinase proteins. Involved in DNA damage response by phosphorylating Y142 of histone H2AX. H2AXpY142 plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Y142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. Two alternatively-spliced human isoforms have been reported.
UniProt Protein Details:
Protein type:Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator; Kinase, protein; EC 2.7.10.2; DNA replication; ATYPICAL group; BAZ family
Biological Process: chromatin-mediated maintenance of transcription; double-strand break repair; heart morphogenesis; histone phosphorylation; positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; response to DNA damage stimulus
NCBI Summary:
This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]
Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2
