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Bax Polyclonal Antibody (CAB11931)

SKU:
CAB11931
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€139 - €489
Frequently bought together:

Description

Bax Polyclonal Antibody (CAB11931)

The Bax Polyclonal Antibody (CAB11931) is specifically designed for research involving the Bax protein, a key player in the regulation of apoptosis, or programmed cell death. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Bax protein, this antibody enables the detection and analysis of Bax expression in various cell types, making it an ideal tool for studies in cell biology, cancer research, and apoptosis regulation.Bax, a pro-apoptotic protein belonging to the Bcl-2 protein family, plays a crucial role in the initiation of the intrinsic pathway of apoptosis.

Dysregulation of Bax expression or function is associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the mechanisms underlying Bax-mediated apoptosis is vital for developing targeted therapies that can either promote or inhibit cell death in disease contexts.Overall, the Bax Polyclonal Antibody (CAB11931) offers researchers a valuable tool for investigating the role of Bax in cell death pathways and its implications for disease development and treatment strategies.

Product Name:Bax Polyclonal Antibody
Product Code:CAB11931
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:2000, IF/ICC 1:50-1:100
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:HeLa, RAW 264.7
Cellular Location:Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein
Customer Validation:IF(HK2)

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse Bax (NP_001179.1).
Sequence:MASGQ GPGPP RQECG EPALP SASEE QVAQD TEEVF RSYVF YRHQQ EQEAE GVAAP ADPEM VTLPL QPSST MGQVG RQLAI IGDDI NRRYD SEFQT MLQHL
Synonyms:BCL2L4
Calculated MW:21kDa
Observed MW:21kDa

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