The BARX1 Polyclonal Antibody (PAC04206) is a valuable tool for researchers studying BARX1, a transcription factor involved in developmental processes, particularly in the formation of tissues and organs such as the stomach and teeth. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BARX1 protein, this antibody allows for the detection and analysis of BARX1 expression in a variety of cell types, making it suitable for investigations in developmental biology and regenerative medicine.BARX1 is known for its critical role in the regulation of gene expression during embryonic development, playing a key role in the differentiation and patterning of various tissues.
Its involvement in the development of specific organs and structures highlights its importance in understanding the molecular mechanisms underlying normal development and potential abnormalities that may lead to congenital disorders. Research on BARX1 holds promise for insights into developmental processes and may offer implications for therapeutic strategies aimed at addressing developmental defects and regenerative medicine approaches.
Western blot. All lanes: BARX1 antibody at 6µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: CEM whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 28, 12 kDa. Observed band size: 28 kDa.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO42206 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42206 at dilution of 1:100.
Background:
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter.
Synonyms:
Homeobox protein BarH-like 1, BARX1
UniProt Protein Function:
BARX1: Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter. Belongs to the BAR homeobox family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 9q12Cellular Component: nucleusBiological Process: nervous system development; organ development; regulation of transcription from RNA polymerase II promoter; tissue development
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008]
