The AUP1 Polyclonal Antibody (PACO07954) is a crucial tool for researchers studying the function of AUP1, a protein involved in lipid metabolism and ER-associated degradation. This antibody, generated in rabbits, specifically targets AUP1 in human samples and is validated for use in Western blot applications. By binding to the AUP1 protein, this antibody allows for the accurate detection and analysis of AUP1 in various cell types, making it essential for studies in lipid biology and protein quality control mechanisms.
AUP1 is a key player in maintaining cellular homeostasis by regulating lipid droplet formation and turnover, as well as ERAD pathways. Dysregulation of AUP1 has been linked to lipid disorders, neurodegenerative diseases, and metabolic syndromes, highlighting its importance in cellular health and function. By studying the role of AUP1, researchers can gain insights into potential therapeutic targets for treating lipid-related disorders and improving cellular quality control mechanisms.
AUP1: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; Endoplasmic reticulumChromosomal Location of Human Ortholog: 2p13Cellular Component: integral to endoplasmic reticulum membrane; membraneMolecular Function: protein binding; ubiquitin bindingBiological Process: ER-associated protein catabolic process; retrograde protein transport, ER to cytosol
UniProt Protein Details:
NCBI Summary:
The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
