The ATP5S Polyclonal Antibody (PACO00443) is a valuable tool for researchers studying ATP5S, a protein essential for cellular energy production in mitochondria. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blotting applications. It accurately detects ATP5S protein, allowing for detailed analysis in a variety of cell types, making it an ideal choice for investigations in bioenergetics and mitochondrial function.ATP5S is a key subunit of ATP synthase, the enzyme responsible for generating ATP in the mitochondria through oxidative phosphorylation. Disruption of ATP5S function can lead to impaired energy production and have significant implications for cellular metabolism and overall health.
Research into ATP5S is crucial for understanding mitochondrial dysfunction in diseases such as metabolic disorders, neurodegenerative diseases, and cancer.By using the ATP5S Polyclonal Antibody, researchers can gain valuable insights into the role of ATP5S in cellular energy metabolism and its potential as a therapeutic target for various diseases. Its specificity and reliability make it an essential tool for investigating the complex mechanisms of mitochondrial function and energy production.
Antibody Name:
ATP5S Antibody
Antibody SKU:
PACO00443
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human ATP5S.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ATP5S; ATPW; ATP synthase subunit s; mitochondrial; ATP synthase-coupling factor B; FB; Mitochondrial ATP synthase regulatory component factor B
UniProt Protein Function:
ATP5S: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Belongs to the ATP synthase subunit s family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 14q21.3Cellular Component: proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial inner membraneMolecular Function: metal ion binding; hydrogen ion transmembrane transporter activityBiological Process: cellular metabolic process; proton transport; mitochondrial ATP synthesis coupled proton transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
NCBI Official Symbol:
ATP5SÂ Â
NCBI Official Synonym Symbols:
FB; ATPW; HSU79253Â Â
NCBI Protein Information:
ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; ATP synthase coupling factor B-like 1; ATP synthase coupling factor B, mitochondrial; mitochondrial ATP synthase regulatory component factor B; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
UniProt Protein Name:
ATP synthase subunit s, mitochondrial
UniProt Synonym Protein Names:
ATP synthase-coupling factor B; FB; Mitochondrial ATP synthase regulatory component factor B
