The ATP2C1 Polyclonal Antibody (CAB2515) is specifically designed for research involving ATP2C1, a transmembrane protein that plays a crucial role in calcium homeostasis and ion transport in cells. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunofluorescence applications.ATP2C1 is a key regulator of calcium signaling within cells, making it essential for various cellular processes including muscle contraction, nerve signaling, and enzyme activation. Dysregulation of ATP2C1 has been implicated in diseases such as Darier's disease, a genetic skin disorder characterized by abnormal calcium levels in the skin cells.
The ATP2C1 Polyclonal Antibody enables precise detection and analysis of ATP2C1 protein levels in different cell types, making it an invaluable tool for researchers studying calcium signaling, ion transport, and related pathways. Understanding the function and regulation of ATP2C1 is essential for unraveling the mechanisms underlying various diseases and developing targeted therapies to modulate calcium homeostasis.
Product Name:
ATP2C1 Rabbit Polyclonal Antibody
SKU:
CAB2515
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ATP2C1 (NP_001186114.1).
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
27032
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP2C1 Rabbit pAb (CAB2515) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
